The initial effects of treatment become visible within 48 to 72 hours. The maximum effect is reached in about 2 weeks. Your facial expression will become more relaxed but by no means mask like. The overall effect is very natural. The effect of treatment generally lasts for 4-6 months. You will notice a gradual fading of its effects. Re-treatment is then required. The longer that you have treatments, the less frequent that you will need it.